Investigation
Research areas
Thanks to our specialization in biological solutions and leadership in managing the different areas of molecular biology, we focus on research in the following areas:
Animal health
We lead research related to vaccines and diagnostic tests for animal health because we work for the progress and evolution of the veterinary market through the use of molecular biology.
We select the most suitable microorganisms for the elaboration of biologicals and we control the entire elaboration process to evaluate possible losses of genetic information.
We provide high quality and integrity of the vaccine antigen since we use the latest technology.
In this area we are known for developing products backed by our advances and the use of state-of-the-art technologies.
Medicine
We collaborate in research aimed at controlling the inputs associated with the different botulinum toxins and their therapeutic applications. We participate in the investigation of key inputs for diagnostic tests such as Dengue.
Agriculture
We focus part of our research on the genetic controls of the bacteria that are used in the production of biological products such as inoculants and biofertilizers, among others. They are very useful for the development of crops and food products.
Strategic Alliances
Strategic alliances and collaborations with peers and colleagues within the industry, with academic and government institutions, have allowed us to acquire and transfer technologies, and develop solutions that facilitate our access to new markets.
Some of our notable alliances are:
- Biochemiq-Inta Castelar: 2009-2018. Joint studies on Leptospira.
- Biochemiq-Inta Bariloche: 2010. Isolation and molecular characterization of Corynebactrium pseudotuberculosis strains for the development of the Biological product.
- Biochemiq-Fontar: 2004-2020. recombinant protein development grant
- Biochemiq-Labovet Brasil: 2013. Technology transfer and development of the Biochemiq do Brasil line of biologics.
- Biochemiq-Bayer Argentina: 2006. Anthrax and Bovine Brucellosis marketing agreement.
- Biochemiq-Calier Argentina: 2019. Elaboration of a line of biologicals.
We develop our own technological support
Molecular Biology Supported (MBS)®
Our products are subjected to strict control at the genetic level that allows us optimal levels of effectiveness.
Molecular Biology Supported (MBS)®, is an advanced support based on molecular techniques to carry out the study of microorganisms at the genetic level. This deepening of knowledge allows us to optimize preventive actions in herds and develop products with key quality standards for broad protection, since we verify the presence and necessary quality of each strain to induce the best immune response.
The knowledge provided in the molecular field through the MBS complements the traditional concepts with a new perspective on biological solutions, since it grants control over previously uncontrolled variables and provides rational explanations for unrelated or unrelated events.c
That allows us?
- Carry out a selection at the genetic level of the most suitable microorganisms for the production of biologicals.
- Control the production process and avoid possible loss of genetic information.
- Evaluate if the original characteristics of the commercial product are preserved until its expiration.
- Deepen information on field strains, their behavior and epidemiology, making preventive actions more effective.
- Master previously uncontrolled key variables.
- Obtain constant quality levels.
Quality levels
Recent outstanding scientific contributions
Brucellosis
In conjunction with the National Agri-Food Health and Quality Service (SENASA) and the Faculty of Veterinary Sciences of the UBA, the molecular typing of Brucella Abortus C-19 (vaccinal strain of the National Plan of Eradication and Control of Bovine Brucellosis). This makes it possible to identify this strain and differentiate it from others through a rapid procedure based on molecular techniques. Work published in the magazine of the Argentine Association of Microbiology, year 2005.
Clostridial diseases
We incorporate a series of molecular controls to the classic microbiological quality control. They consist of verifying the presence of the genes responsible for the generation of toxins. This control is carried out at the beginning of the elaboration and throughout the process, which translates into high toxin titers for biological products.
Leptospirosis
Together with the National Institute of Agricultural Technology (INTA), we developed the analysis of the genetic diversity of different strains of clinical cases of Leptospira interrogans through molecular techniques. This study allows the improvement of vaccines, epidemiological and diagnostic analyzes in our country. Published in Comparative Immunology, Microbiology & Infectious Diseases 2008; Epub, May 24, 2007.
Carbuncle
We apply molecular controls to the Sterne strain of Bacillus anthracis, used in the preparation of vaccines for the prevention of Anthrax. These controls guarantee the presence of genes that, according to the guidelines of the International Organization of Epizootics (OIE), code for the proteins that generate the immune response.
We carried out the first molecular epidemiology study and analyzed different strains of Bacillus anthracis, including strains from clinical cases, vaccinations, and international reference strains. This study helps to predict future behavior of the strains and to evaluate control measures in a rational way. This work has been presented at the International Symposium of the International Association of Veterinary Diagnostic Laboratories, year 2005.
Viral
At Biochemiq we carry out the molecular control of the virus strains used for the preparation of viral vaccines. Tests include: identification and differentiation of bovine herpesvirus types 1 and 5, typing of rotavirus strains used in bovine vaccines, detection of bovine viral diarrhea virus and parainfluenza virus 3 (both cases, highly conserved regions of their genome are analyzed). Bovine and monkey cell lines used for culturing these viruses are also molecularly controlled at the species level. We are also advancing in the molecular diagnosis of bovine respiratory syncytial virus and various types of equine herpes virus.
